Are Nonsynonymous Transversions Generally More Deleterious than Nonsynonymous Transitions?
نویسندگان
چکیده
منابع مشابه
Prediction of Deleterious Nonsynonymous Single-Nucleotide Polymorphism for Human Diseases
The identification of genetic variants that are responsible for human inherited diseases is a fundamental problem in human and medical genetics. As a typical type of genetic variation, nonsynonymous single-nucleotide polymorphisms (nsSNPs) occurring in protein coding regions may alter the encoded amino acid, potentially affect protein structure and function, and further result in human inherite...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2020
ISSN: 1537-1719
DOI: 10.1093/molbev/msaa200